Association between mercury in cord serum and sex-specific DNA methylation in cord tissues
نویسندگان
چکیده
منابع مشابه
Sex differences in DNA methylation of the cord blood are related to sex-bias psychiatric diseases
Sex differences in the prevalence of psychiatric disorders are well documented, with exposure to stress during gestation differentially impacting females and males. We explored sex-specific DNA methylation in the cord blood of 39 females and 32 males born at term and with appropriate weight at birth regarding their potential connection to psychiatric outcomes. Mothers were interviewed to gather...
متن کاملAssociation between umbilical cord
Background: Animal data show that decreased activity of placental 11-beta-hydroxysteroid dehydrogenase type 2 (11β-HSD2), which potently inactivates glucocorticoids (e.g. cortisol) to inert forms (cortisone), allows increased access of maternal glucocorticoids to the fetus and 'programs' hypertension. Data in humans are limited. We examined in humans the association between venous umbilical cor...
متن کاملCord blood buffy coat DNA methylation is comparable to whole cord blood methylation.
Cord blood DNA methylation is associated with numerous health outcomes and environmental exposures. Whole cord blood DNA reflects all nucleated blood cell types, while centrifuging whole blood separates red blood cells, generating a white blood cell buffy coat. Both sample types are used in DNA methylation studies. Cell types have unique methylation patterns and processing can impact cell distr...
متن کاملDNA methylation signatures in cord blood of ICSI children
STUDY QUESTION Does ICSI induce specific DNA methylation changes in the resulting offspring? SUMMARY ANSWER Although several thousand analyzed CpG sites (throughout the genome) displayed significant between-group methylation differences, both ICSI and spontaneously conceived children varied within the normal range of methylation variation. WHAT IS KNOWN ALREADY Children conceived by ART hav...
متن کاملPrenatal Exposure to Mercury: Associations with Global DNA Methylation and Hydroxymethylation in Cord Blood and in Childhood
BACKGROUND Mercury is a global pollutant, and prenatal exposure is associated with adverse health effects. To date, no studies have evaluated the association between prenatal mercury exposure and DNA hydroxymethylation, an epigenetic modification important for tissue differentiation and embryonic development. OBJECTIVES We sought to evaluate the association between prenatal mercury exposure a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Developmental Origins of Health and Disease
سال: 2020
ISSN: 2040-1744,2040-1752
DOI: 10.1017/s2040174420000161